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VectorBase News for A. aegypti
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New expression data: insecticide resistant Vauclin strain » |
| Posted by Bob MacCallum on November 03rd, 2009
Detoxification genes were assayed for expression differences between two strains of Aedes aegypti: Vauclin, from Martinique, which is resistant to temephos and deltamethrin insecticides, and Bora-bora, which is susceptible to insecticides, in both larvae and adults.
The open access article can be found here, and many of the genes mentioned in the paper now have official VectorBase gene symbols, so you can locate their expression pages easily with the following style of URL: http://funcgen.vectorbase.org/ExpressionData/gene/CYP6M6.
This work was a collaborative effort between the Laboratoire d'Ecologie Alpine (LECA) of Grenoble, the Institut de Recherche pour le Développement (IRD) Montpellier, and the LSTM, Liverpool.
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New Aedes aegypti gene set update » |
| Posted by Karyn Megy on September 15th, 2009
A new Aedes aegypti gene set, AaegL1.2, is now accessible at
VectorBase
The update is includes gene models which were deemed supplemental to the initial set and models submitted by the community (to learn how to submit your gene models to VectorBase, click
here).
The new gene set also includes an update of the expression and comparative data.
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New Aedes aegypti detox expression data » |
| Posted by Bob MacCallum on March 20th, 2009
A new experiment profiling the response of detoxification genes to 72h exposure to 2 pesticides and 3 insecticides in Aedes aegypti larvae has been released in VectorBase. The publication is in press and we'll let you have the details as soon as we know them.
Here's a link to Table 2 from the forthcoming paper (Google Docs) with hyperlinks to the VectorBase expression reports.
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Detox time: larval expression profiles for 5 xenobiotics » |
| Posted by Bob MacCallum on January 24th, 2008
By using the Aedes detox chip microarray, researchers from the French
Laboratory of Alpine Ecology of Grenoble (R. Poupardin, S. Reynaud and
J.P. David), the Liverpool School of Tropical Medicine (C. Strode and
H. Ranson) and the Greek Laboratory of Pesticide Science (J. Vontas) compared
the expression of candidate detoxification genes in Aedes aegypti
larvae exposed to two insecticides and three pollutants commonly found in
polluted environments. This study allowed the isolation of genes that are
induced by distinct subsets of insecticides and pollutants (e.g. AAEL001807/CYP9M9
is induced by atrazin, permethrin and fluoranthen while
AAEL009127/CYP6M11
responds to copper sulfate). Results
of this research work will contribute to decode the molecular mechanisms of
xenobiotic response in mosquitoes and the possible impact of pollutants on
insecticide tolerance. This study will be published shortly in the journal
Insect Biochemistry and Molecular Biology as (Poupardin et al., 2008). The
expression data is available in VectorBase from today.
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